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KMID : 1011320180100020087
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Journal of Pharmacoepidemiology and Risk Management
2018 Volume.10 No. 2 p.87 ~ p.90
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A Case of Stevens-Johnson Syndrome Repeatedly Induced by Roxithromycin and Clarithromycin
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Kim Su-Jeong
Park Han-Ki
Lee Jong-Myung
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Abstract
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Macrolides have been considered as safe antibiotics that rarely cause hypersensitivity reactions. However, as macrolides have been widely prescribed for various diseases due to its antimicrobial and immunomodulatory properties, reports of hypersensitivity reactions caused by these drugs have also increased. Although cross-reactions among macrolide antibiotics are known to be uncommon, studies about macrolides cross-reactivity are scarce so far. We have recently experienced a rare case of Stevens-Johnson syndrome (SJS) probably induced by roxithromycin. The patient repeated the same adverse reactions after taking clarithromycin. Clinicians should consider macrolides as one of the culprit drugs of severe cutaneous adverse reaction such as SJS, and be aware of the potential for cross-reaction between macrolides.
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KEYWORD
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Stevens-Johnson syndrome, Macrolides, Roxithromycin, Clarithromycin, Cross reactions, Drug hypersensitivity
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